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The writers would wish to give thanks to Shuangying Liu and R. Mathew Thomas through the ARIAD Chemistry office due to their help in preparing AP24283 and AP24163 as well as their analogs, as well as Jeff Keats and Qihong Xu of the ARIAD Biology office for supplying chemical and cell assay facts. Furthermore we acknowledge Feng Li and Allyn Martin because of their technical support, Manfred Weigele, David Berstein and winner Rivera of ARIAD with regards to their statements and enthusiastic help for this work.

Acknowledgments

Nilotinib (AMN-107), a second-generation DFG-out substance originated to boost the effectiveness of imatinib-like particles against Abl, and therefore to get over many of the imatinib resistant mutations ( 22, 23 ). Continue reading →